South African Thalassaemia Association

Phone: +27 (0)31 413 442
Contact Person: Mr D. Brijball

Thalassaemia refers to a group of diseases seen mainly in the Asian, Greek, Cypriote, Italian and ‘mixed population groups". For Beta-Thalassaemia the carrier frequency in these population groups is high (about 1-3 per 100). B-Thalassaemia is a severe haemolytic anaemia due to absent or deficient synthesis of b -globin. This in turn is due to a mutation in the b gene complex on chromosome 11. Affected individuals usually have severe hepatosplenomegaly. They require regular iron chelation therapy and blood transfusions every 4-8 weeks.

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